The compound according to claim 4, wherein the radionuclide A is chelated according to the structure:Ħ.
The compound according to claim 1, wherein Q represents a monoclonal antibody with binding affinity for targets selected from the list consisting of FAP, HER2, and PSMA.Ĥ.
The compound according to claim 1, wherein Q represents the following structure: wherein X represents aryl, heteroaryl, butylurea, fluoro-substituted phenyl, butyl-substituted phenyl, quinolinyl and 2-napthyl wherein Y represents aryl, heteroaryl, aralkyl, hetaralkyl, C 3-C 8-cycloalkyl, or pyridine wherein G represents CH 2N*H or N*H with * being the attachment point to the remainder of compound (I) and wherein R 5 represents azole, -SO 2H, -SO 3H, -SO 4H, -PO 2H, -PO 3H 2, -PO 3H, -PO 4H 2, -CO 2H, -C(O)R wherein R represents -H, -OH, -(C 1-C 10)alkyl, -O(C 1-C 10)alkyl, -NHR 6, or NR 6R 7 R 6, R 7 and R 8 each independently represent H, bond, (C 1-C 10)alkylene, F, Cl, BR, I, C(O), C(S), -C(S)-NH-benzyl-, -C(O)-NH-benzyl-, -C(O)-(C 1-C 10)alkylene, -(CH 2)v-NR 8, -(CH 2)p-NH-C(O)-(CH 2)p-, -(CH 2-CH 2)t-NH-C(O)-(CH 2)p-, -(CH 2)p-COR, -(CH 2)p-C(O)NH-C 3, -C 3, or -(CH 2)p-(C 5-C 14)heteroaryl wherein v, p and t are independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 or a stereoisomer, a hydrate, a solvate, or a salt thereof, or a mixture of same.ģ.
A compound of formula (I): wherein: n is 1, 2 or 3 R1, R2, R3 and R4, independently represent OH or Q and Q represents a tissue-targeting moiety selected from the group consisting of poly- and oligo-peptides, proteins, DNA and RNA fragments, aptamers polyclonal or monoclonal antibodies, and a mixture of proteins or fragments or constructs of protein or a stereoisomer, a hydrate, a solvate, or a salt thereof, or a mixture of same.Ģ.
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